Directx 11 in this case, played bg3 on Linux and that was the only option that worked, and it did work quite well.
As for when to use one or the other, just check protondb. People usually leave what they played on, they even leave some useful launch commands or solutions to issues that could possibly arise, so it’s always worth a look.
It’s not really surprising - historically, the creation Israel state was helped massively by antisemitists, who wanted to get rid of jews in their own country and having them a place to immigrate to would be the easiest option (the phenomena is often referred to as Zionist antisemitism).
So yeah, it does make sense - they can hate the jews, but also support Israel at the same time.